Learn about Macroglobulinemia Treatment in India — how it works, who it is for, recovery timelines, and what to expect before and after surgery. Compare hospitals and doctors experienced in Macroglobulinemia and request assistance for cost estimates or appointments.

About Macroglobulinemia

Macroglobulinemia, specifically Waldenström macroglobulinemia (WM), is a rare, chronic lymphoproliferative disorder managed by specialists in Internal Medicine, particularly Hematology-Oncology. It is characterized by the overproduction of a monoclonal immunoglobulin M (IgM) protein by malignant lymphoplasmacytic cells in the bone marrow. This excess IgM thickens the blood, leading to hyperviscosity syndrome, which can cause symptoms like fatigue, bleeding, vision problems, and neurological issues. Diagnosis involves blood tests, bone marrow biopsy, and imaging. Treatment is not always immediate and is tailored to symptoms; options include targeted therapies, chemotherapy, immunotherapy, and plasmapheresis to manage viscosity. The goal is long-term disease control and symptom management.

Key Highlights

    Provides a definitive diagnosis for a complex blood disorder.Enables personalized treatment planning based on genetic and molecular markers.Offers long-term management strategies to control symptoms and improve quality of life.Involves a multidisciplinary approach led by Internal Medicine specialists.Focuses on managing complications like hyperviscosity syndrome effectively.

Who is this surgery for?

  • Unexplained symptoms such as persistent fatigue, weakness, or unexplained weight loss.
  • Signs of hyperviscosity syndrome: blurred vision, headaches, dizziness, or bleeding from the nose or gums.
  • Enlarged lymph nodes, liver, or spleen (hepatosplenomegaly).
  • Abnormal blood test results showing high IgM levels, anemia, or low platelet counts.
  • Neurological symptoms like peripheral neuropathy (numbness, tingling) or confusion.
  • Recurrent infections due to impaired immune function.

How to prepare

  • Comprehensive consultation with a hematologist-oncologist to review medical history and symptoms.
  • A series of diagnostic blood tests, including serum protein electrophoresis and quantitative immunoglobulins.
  • Imaging studies like CT scans to assess lymph nodes and organs.
  • Preparation for a bone marrow aspiration and biopsy, which may involve fasting and arranging for post-procedure transport.
  • Discussion of all current medications and supplements with the doctor.
  • Psychological preparation and counseling regarding the chronic nature of the condition.

Risks & possible complications

  • Complications from bone marrow biopsy: pain, bleeding, or infection at the site.
  • Side effects of systemic therapies: nausea, fatigue, lowered blood counts, and increased infection risk.
  • Infusion-related reactions from biologic or immunotherapy drugs.
  • Progression of hyperviscosity leading to stroke, heart failure, or severe bleeding.
  • Transformation to a more aggressive lymphoma (rare).
  • Long-term risks of secondary cancers from certain treatments.

Recovery & hospital stay

  • Recovery from diagnostic procedures like bone marrow biopsy is quick, with rest advised for 24 hours.
  • Management is long-term, involving regular follow-up visits for blood tests and monitoring.
  • Patients may need periodic plasmapheresis sessions to manage high IgM levels.
  • Adherence to prescribed oral or intravenous therapy schedules is crucial.
  • Lifestyle adjustments, including a balanced diet and moderate exercise as tolerated, are recommended.
  • Prompt reporting of new symptoms like fever, severe headaches, or unusual bleeding to the healthcare team is essential.
  • checked Typical hospital stay: Varies (Outpatient to several days)
  • checked Expected recovery time: Ongoing management

Frequently Asked Questions

If you are considering macroglobulinemia in India, these questions and answers can help you make a confident, informed decision.

Procedure cost in other countries

Here is an overview of how the estimated cost, hospital stay, and recovery time for macroglobulinemia compare across other countries where we have data.

Country Estimated cost range Typical stay Recovery time View details
India USD 544 – USD 8,701 Varies (Outpatient to several days) ~ Ongoing management Know More
Turkey USD 4,026 – USD 64,420 Varies (Outpatient to several days) ~ Ongoing management Know More

Top hospitals for Macroglobulinemia in India

These partner hospitals in India have dedicated internal medicine teams and experience managing patients undergoing macroglobulinemia.

Artemis Hospital Gurgaon

  • IconGurgaon, India
  • Icon141 Doctors

Manipal Hospital Siliguri

  • IconSiliguri, India
  • Icon30 Doctors

Manipal Hospital Salt Lake

  • IconKolkata, India
  • Icon129 Doctors

KMC Hospital Mangalore

  • IconMangalore, India
  • Icon38 Doctors

Manipal Hospital Ranchi

  • IconRanchi, India
  • Icon41 Doctors

Manipal Hospital EM Bypass

  • IconKolkata, India
  • Icon94 Doctors

Manipal Hospital Ghaziabad

  • IconGhaziabad, India
  • Icon43 Doctors

Manipal Hospital Malleshwaram

  • IconBangalore, India
  • Icon105 Doctors
PATIENT REVIEW

My 82-year-old father was admitted with...

My 82-year-old father was admitted with severe pneumonia and multiple complications. Dr. Suhas MS not only managed his complex condition with expertise but took the time to explain every medication change to our family. His compassionate approach made a frightening situation manageable, and Dad is now recovering beautifully at home.

Internal Medicine Specialists for Macroglobulinemia

Explore experienced internal medicine specialists who regularly perform macroglobulinemia and provide pre- and post-operative care in India.

Dr. Abhishek M
  • 15 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Millers Road

OPD-desk synced • Updated
Dr. Sunil Havannavar
  • 24 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Sarjapur Road

OPD-desk synced • Updated
Dr. Santanu Ganguly
  • 21 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospitals Broadway

OPD-desk synced • Updated
Dr. Sneha S
  • 16 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Kanakapura Road

OPD-desk synced • Updated
Dr. K Vengadakrishnan
  • 23 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi, Tamil

MediFyr Plus SIMS Hospital Vadapalani

OPD-desk synced • Updated
Dr. Ujjal Chakravarty
  • 14 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Dhakuria

OPD-desk synced • Updated
Dr. Suman Halder
  • 17 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Dhakuria

OPD-desk synced • Updated
Dr. Mugdha Lakhotia
  • 10 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Sarjapur Road

OPD-desk synced • Updated
Dr. Haroon Hussain
  • 11 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus KMC Hospital Mangalore

OPD-desk synced • Updated
Dr. Dilip Raj K S
  • 14 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Varthur Road

OPD-desk synced • Updated
Dr. Ashutosh Kumar Thakur
  • 18 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Ranchi

OPD-desk synced • Updated
Dr. Ch Manoj Kumar
  • 33 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Vijayawada

OPD-desk synced • Updated
Dr. Rajini Surendra
  • 24 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Doddaballapur

OPD-desk synced • Updated
Dr. Ravi Kumar V N
  • 24 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Yeshwanthpur

OPD-desk synced • Updated
Dr. Prasad Biware
  • 23 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Baner

OPD-desk synced • Updated
Dr. Barun Kumar Datta
  • 11 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospitals Broadway

OPD-desk synced • Updated
Dr. Pavan M R
  • 17 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus KMC Hospital Mangalore

OPD-desk synced • Updated
Dr. Mayur Bahan Mukherji
  • 19 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Dhakuria

OPD-desk synced • Updated
Dr. Ashar Hasan
  • 10 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospitals Broadway

OPD-desk synced • Updated
Dr. Shankar V
  • 28 Years Experience
  • Internal Medicine Specialist
Speaks: English, Hindi
Next available on
02/Feb: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Malleshwaram

OPD-desk synced • Updated
Next