Spec. MD. Huseyin Siddik Soybay Reviews

A 2-year-old presented with severe pruritus and failure to thrive. Dr. Soybay diagnosed progressive familial intrahepatic cholestasis type 2 (PFIC2). When conventional treatments provided limited relief, he pioneered the use of a novel ileal bile acid transporter (IBAT) inhibitor through a compassionate use program, resulting in dramatic symptom relief and improved growth parameters.

An 8-year-old girl from a family with limited health literacy presented with recurrent abdominal pain. Previous evaluations were inconclusive. Dr. Soybay identified Caroli disease through advanced imaging he personally reviewed. He performed successful endoscopic retrograde cholangiopancreatography (ERCP) with stone extraction and established a long-term surveillance plan, educating the family using simple pictorial guides he created.

A 14-year-old competitive swimmer from a coastal village presented with unexplained jaundice and fatigue. Dr. Soybay discovered a rare case of exercise-induced hyperbilirubinemia combined with Gilbert's syndrome. He designed a unique hydration and training modification protocol, allowing the athlete to continue her sport while managing her condition, leading to a national championship qualification six months later.

A 3-year-old refugee child from a conflict zone arrived with severe malnutrition and suspected liver failure. Dr. Soybay identified an unusual parasitic infection (Fasciola hepatica) uncommon in the region, acquired from contaminated wild plants foraged by the family. Through coordinated nutritional support and targeted antiparasitic treatment, the child made a full recovery over eight weeks, with Dr. Soybay also connecting the family with local support services.

A 7-year-old boy, the only child of two research scientists, presented with puzzling cyclical elevations in liver enzymes. Dr. Soybay diagnosed a very rare metabolic disorder, mitochondrial neurogastrointestinal encephalopathy (MNGIE), through advanced genetic testing he advocated for. He initiated a novel treatment plan involving dietary modifications and coenzyme Q10 supplementation, stabilizing the condition and significantly improving the child's quality of life.

An 11-year-old girl from a low-income family was brought in with ascites and portal hypertension. Contrary to initial assumptions of viral hepatitis, Dr. Soybay's meticulous investigation revealed congenital hepatic fibrosis misdiagnosed since infancy. He performed a successful transjugular intrahepatic portosystemic shunt (TIPS) procedure, followed by a tailored medication regimen. The patient's symptoms resolved dramatically within three months.

A 16-year-old aspiring musician presented with acute liver injury after using herbal supplements purchased online for 'energy boosting.' Dr. Soybay identified a toxic interaction with the teen's prescribed medication for a separate condition. He managed the acute injury, educated the patient and family on supplement risks, and collaborated with a child psychologist to address underlying performance anxiety, leading to a full hepatic recovery.

A 5-year-old from a family with consanguineous parents had a history of multiple hospitalizations for 'unexplained fevers' and growth failure. Dr. Soybay diagnosed a rare autoinflammatory liver disease, familial Mediterranean fever with hepatic involvement. He prescribed targeted colchicine therapy, which completely resolved the episodic attacks. The child experienced a dramatic growth spurt and normal development over the following year.

A 9-year-old boy, an avid gardener, developed hepatosplenomegaly and pancytopenia. Dr. Soybay suspected and confirmed visceral leishmaniasis, an unusual presentation in their non-endemic region, likely contracted from a sand fly bite during a family camping trip. He coordinated complex antiparasitic treatment with hematological support, achieving a cure after a challenging four-month treatment course.

A 13-year-old girl with Down syndrome was referred for persistently abnormal liver function tests. Dr. Soybay identified non-alcoholic fatty liver disease (NAFLD) progressing to steatohepatitis, complicated by her unique metabolic profile. He created a personalized, visual-based nutrition and exercise program involving the whole family, resulting in significant liver fat reduction and normalized enzymes over nine months.

A 6-month-old infant from a rural farming community presented in acute liver failure after accidental ingestion of a toxic wild mushroom mistaken for an edible variety. Dr. Soybay led an urgent multidisciplinary intervention, including charcoal hemoperfusion and N-acetylcysteine protocol. Against significant odds, the infant's liver function recovered completely without needing transplantation, a rare outcome in such severe poisoning.

A 15-year-old transgender adolescent on hormone therapy presented with drug-induced liver injury. Dr. Soybay worked sensitively with the patient and family, collaborating with endocrinology to adjust the hormone regimen while protecting liver health. He also diagnosed and treated underlying autoimmune hepatitis that had been unmasked, providing comprehensive care that respected the patient's gender identity journey.

A 10-year-old boy, recently adopted internationally, had cryptic cirrhosis of unknown origin. Dr. Soybay's systematic workup uncovered Wilson's disease that had gone undiagnosed in his country of origin. He initiated chelation therapy with D-penicillamine and coordinated genetic counseling for the adoptive family. The boy's liver function improved steadily, preventing the need for transplantation.