About Intra Cytoplasmic Sperm Injection
Key Highlights
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Highly effective for severe male factor infertility, including very low sperm count or motility.Directly bypasses natural fertilization barriers to achieve fertilization.Can be used with sperm retrieved surgically from the epididymis (PESA) or testicles (TESA/TESE).Offers a solution for previous failed fertilization attempts with standard IVF.Allows for the use of preimplantation genetic testing (PGT) on the resulting embryos.
Who is this surgery for?
- Severe oligozoospermia (very low sperm count) or cryptozoospermia.
- Poor sperm motility (asthenozoospermia) or abnormal sperm morphology (teratozoospermia).
- Obstructive or non-obstructive azoospermia requiring surgical sperm retrieval.
- Previous failed or poor fertilization in a conventional IVF cycle.
- Use of frozen sperm samples with limited quality or quantity.
- In cases requiring preimplantation genetic testing (PGT) of embryos.
- Unexplained infertility where standard IVF has not been successful.
How to prepare
- Complete fertility evaluation of both partners, including semen analysis and female ovarian reserve testing.
- Ovarian stimulation for the female partner to produce multiple mature eggs, monitored via ultrasound and blood tests.
- Sperm sample collection on the day of egg retrieval. For surgical retrieval, the male partner undergoes PESA/TESA/TESE.
- Administration of a trigger shot (hCG or agonist) to induce final egg maturation.
- Egg retrieval is performed transvaginally under sedation 34-36 hours after the trigger shot.
Risks & possible complications
- Standard IVF risks from ovarian stimulation (OHSS) and egg retrieval (bleeding, infection).
- Slight increase in risk of fertilization failure, though ICSI mitigates this.
- Potential for damage to the egg during the injection process, though this is rare with experienced embryologists.
- Very slightly increased theoretical risk of certain genetic and imprinting disorders in offspring, though absolute risk remains low.
- Risk of transferring a genetic cause of male infertility to male offspring.
- Multiple pregnancy risk if more than one embryo is transferred.
Recovery & hospital stay
- Immediate recovery from egg retrieval sedation takes 1-2 hours in the clinic.
- Mild cramping, bloating, or spotting may occur for 1-2 days post-retrieval.
- Patients can typically resume normal, non-strenuous activities the next day.
- Embryo transfer is usually scheduled 3-5 days after egg retrieval, requiring no specific recovery.
- Post-transfer, light activity is recommended; avoid strenuous exercise, heavy lifting, and hot baths for a few days.
- A pregnancy blood test (beta-hCG) is performed approximately 10-14 days after embryo transfer.
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Typical hospital stay: 0 days (Outpatient procedure)
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Expected recovery time: 1-2 days (for egg retrieval procedure)
Frequently Asked Questions
If you are considering intra cytoplasmic sperm injection in India, these questions and answers can help you make a confident, informed decision.
Top-rated hospitals in India with ivf and reproductive medicine departments and experienced surgeons are ideal for this procedure. Use MediFyr to compare facilities, reviews, and doctor profiles before you decide.
Look at the doctor’s years of experience, hospital association, patient reviews, and how often they perform intra cytoplasmic sperm injection. MediFyr helps you compare ivf and reproductive medicines and book consultations online.
The overall cost depends on hospital category, surgeon’s experience, room type, implant or device used (if any), length of stay, tests, and post-operative care. Our team can help you get cost estimates from multiple hospitals before you decide.
Procedure cost in other countries
Here is an overview of how the estimated cost, hospital stay, and recovery time for intra cytoplasmic sperm injection compare across other countries where we have data.
| Country | Estimated cost range | Typical stay | Recovery time | View details |
|---|---|---|---|---|
| India | INR 150 Thousand – 350 Thousand | 0 days (Outpatient procedure) | ~ 1-2 days (for egg retrieval procedure) | Know More |
| Turkey | TRY 525 Thousand – 1.23 Million | 0 days (Outpatient procedure) | ~ 1-2 days (for egg retrieval procedure) | Know More |
Vihaan Bhatia, a 38-year-old software architect...
Vihaan Bhatia, a 38-year-old software architect from Bangalore, had been trying to conceive with his wife, Priya, for four years. Their journey began with unexplained infertility, but after multiple failed IUI cycles, a semen analysis revealed severe oligoasthenoteratozoospermia, extremely low sperm count, poor motility, and abnormal morphology. The news was devastating for Vihaan, who felt a deep sense of personal failure and guilt. Their fertility specialist, Dr. Mehta, gently explained that natural conception was highly unlikely and recommended ICSI as their best chance. The procedure involved surgically retrieving sperm from Vihaan under anesthesia, a process he found anxiety-inducing but manageable. In the lab, a single healthy sperm was injected directly into each of Priya's retrieved eggs. The two-week wait was agonizing. The outcome was cautiously joyful: a positive pregnancy test, followed by a confirmed singleton pregnancy at their first scan. Vihaan's emotional journey shifted from shame and despair to immense relief and a burgeoning hope. He felt the ICSI procedure had not just given them a chance at a family, but had also lifted a heavy burden of blame from his shoulders.
IVF and Reproductive Medicines for Intra Cytoplasmic Sperm Injection
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