Physiological Intra Cytoplasmic Sperm Injection Treatment in India – Best Hospitals & Doctors

Learn about Physiological Intra Cytoplasmic Sperm Injection Treatment in India — how it works, who it is for, recovery timelines, and what to expect before and after surgery. Compare hospitals and doctors experienced in Physiological Intra Cytoplasmic Sperm Injection and request assistance for cost estimates or appointments.

Partner Hospitals

0 partner in India for this surgery

Specialist Doctors

7 Surgeons linked to this surgery

Treatment Cost

Approx INR 180 Thousand – 350 Thousand

About Physiological Intra Cytoplasmic Sperm Injection

Physiological Intra Cytoplasmic Sperm Injection (PICSI) is an advanced assisted reproductive technology (ART) procedure used in IVF treatment. It is a refined version of conventional ICSI, designed to select the most mature and functionally competent sperm for injection into the egg. Unlike standard ICSI, which selects sperm based on morphology and motility alone, PICSI utilizes a special culture dish coated with hyaluronic acid, a natural compound found in the layer surrounding the human egg. Only mature sperm with intact DNA and proper receptors bind to this hyaluronic acid, mimicking the natural selection process that occurs during fertilization. This physiological selection aims to improve embryo quality, increase implantation rates, and potentially reduce the risk of genetic abnormalities, offering hope for couples with severe male factor infertility or previous IVF failures.

Key Highlights

Employs a physiological, natural selection method using hyaluronic acid to identify the most viable sperm.Aims to improve embryo quality and potential for successful implantation.May help reduce the risk of selecting sperm with DNA fragmentation or chromosomal abnormalities.Particularly beneficial for cases of severe male factor infertility, such as very low sperm count or poor morphology.Can be a recommended option after previous unsuccessful conventional ICSI cycles.

Who is this surgery for?

Severe male factor infertility, including very low sperm count (severe oligozoospermia) or poor sperm morphology (teratozoospermia).
High levels of sperm DNA fragmentation identified through specialized testing.
Recurrent implantation failure or poor embryo development in previous IVF/ICSI cycles.
Unexplained infertility where subtle sperm quality issues may be a factor.
Advanced paternal age, which can be associated with increased sperm DNA damage.

How to prepare

Complete fertility evaluation of both partners, including semen analysis and female partner's ovarian reserve testing.
Consultation with a reproductive specialist to discuss the procedure, its rationale, and expected outcomes.
For the female partner: Ovarian stimulation with fertility medications to produce multiple eggs, monitored via blood tests and ultrasounds.
For the male partner: Provision of a fresh semen sample on the day of the egg retrieval procedure.
Pre-procedure instructions regarding medications, diet, and timing of the final trigger injection to mature the eggs.

Risks & possible complications

Risks associated with ovarian stimulation, such as Ovarian Hyperstimulation Syndrome (OHSS).
Standard IVF risks from egg retrieval, including minor bleeding, infection, or injury to surrounding structures (rare).
No fertilization or poor embryo development, despite sperm selection.
Risk of multiple pregnancy if more than one embryo is transferred.
The procedure does not eliminate all risks of genetic abnormalities or birth defects.

Recovery & hospital stay

Immediately after egg retrieval, rest is advised for the remainder of the day; mild cramping or bloating is common.
Most women can resume normal, non-strenuous activities within 1-2 days.
Patients are advised to avoid strenuous exercise, heavy lifting, and sexual intercourse for a period specified by the doctor (typically 1-2 weeks).
Embryo transfer is usually performed 3-5 days after the retrieval, which is a simple, non-surgical procedure.
Follow-up includes a pregnancy test approximately 10-14 days after the embryo transfer.
Emotional support is important during the two-week wait and throughout the IVF journey.

Typical hospital stay: 0 days (outpatient procedure for egg retrieval and transfer)
Expected recovery time: 1-2 days for post-retrieval recovery; full cycle takes 4-6 weeks

Frequently Asked Questions

If you are considering physiological intra cytoplasmic sperm injection in India, these questions and answers can help you make a confident, informed decision.

＋ − Which hospitals are best for physiological intra cytoplasmic sperm injection in India?

Top-rated hospitals in India with ivf and reproductive medicine departments and experienced surgeons are ideal for this procedure. Use MediFyr to compare facilities, reviews, and doctor profiles before you decide.

＋ − How do I choose the right doctor for physiological intra cytoplasmic sperm injection?

Look at the doctor’s years of experience, hospital association, patient reviews, and how often they perform physiological intra cytoplasmic sperm injection. MediFyr helps you compare ivf and reproductive medicines and book consultations online.

＋ − What factors affect the cost of physiological intra cytoplasmic sperm injection?

The overall cost depends on hospital category, surgeon’s experience, room type, implant or device used (if any), length of stay, tests, and post-operative care. Our team can help you get cost estimates from multiple hospitals before you decide.

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INR 180 Thousand – 350 Thousand
Typical stay: 0 days (outpatient procedure for egg retrieval and transfer)
Recovery: ~1-2 days for post-retrieval recovery; full cycle takes 4-6 weeks

Procedure cost in other countries

Here is an overview of how the estimated cost, hospital stay, and recovery time for physiological intra cytoplasmic sperm injection compare across other countries where we have data.

Country	Estimated cost range	Typical stay	Recovery time	View details
India	INR 180 Thousand – 350 Thousand	0 days (outpatient procedure for egg retrieval and transfer)	~ 1-2 days for post-retrieval recovery; full cycle takes 4-6 weeks	Know More
Turkey	TRY 630 Thousand – 1.23 Million	0 days (outpatient procedure for egg retrieval and transfer)	~ 1-2 days for post-retrieval recovery; full cycle takes 4-6 weeks	Know More

PATIENT REVIEW

Sara Miller, 38, is a high...

Sara Miller, 38, is a high school biology teacher who has always dreamed of having a family. After trying to conceive naturally for three years with her husband, Mark, they sought help. Initial tests revealed Mark had severe oligospermia, with very few sperm present in his ejaculate. Their fertility specialist, Dr. Evans, explained that even conventional IVF was unlikely to succeed due to the low sperm count and poor motility. He recommended Physiological Intra Cytoplasmic Sperm Injection (PICSI), a more advanced form of ICSI that selects the most mature and healthy sperm by binding to hyaluronic acid, mimicking the natural selection process in the female body. Sara underwent ovarian stimulation and egg retrieval, which was physically taxing but manageable. In the lab, embryologists used PICSI to carefully select a single sperm for each of Sara's 11 mature eggs. The procedure itself was a tense waiting game for the couple. The emotional journey was a rollercoaster of hope and fear; Sara felt a deep sense of biological failure and anxiety about their chances. Five days later, they received the call that six embryos had developed successfully. Two were transferred, and a subsequent pregnancy test was positive. Sara's recovery from the retrieval was swift, and she is now 14 weeks pregnant. The outcome has transformed their anxiety into cautious joy and profound gratitude for the precise science that made their dream possible.

IVF and Reproductive Medicines for Physiological Intra Cytoplasmic Sperm Injection

Explore experienced ivf and reproductive medicines who regularly perform physiological intra cytoplasmic sperm injection and provide pre- and post-operative care in India.