Learn about Preimplantation Genetic Diagnosis Treatment in India — how it works, who it is for, recovery timelines, and what to expect before and after surgery. Compare hospitals and doctors experienced in Preimplantation Genetic Diagnosis and request assistance for cost estimates or appointments.

About Preimplantation Genetic Diagnosis

Preimplantation Genetic Diagnosis (PGD) is an advanced reproductive technology performed during an IVF cycle to screen embryos for specific genetic disorders or chromosomal abnormalities before implantation. This procedure involves extracting one or more cells from a developing embryo, typically at the blastocyst stage (day 5 or 6), and analyzing its DNA. The primary goal is to identify and select embryos free of the targeted condition, thereby significantly reducing the risk of passing on inherited genetic diseases to offspring and improving the chances of a successful, healthy pregnancy. PGD is a powerful tool for couples with a known history of genetic disorders, recurrent miscarriages, or previous IVF failures, offering a proactive approach to family planning and reproductive health.

Key Highlights

    Allows for the selection of embryos free from specific genetic disorders before pregnancy begins.Significantly reduces the risk of passing on inherited conditions like cystic fibrosis, Huntington's disease, or chromosomal abnormalities.Can help improve IVF success rates by identifying chromosomally normal embryos with higher implantation potential.Provides valuable information for family planning, especially for couples with a known genetic carrier status.May reduce the emotional and physical burden associated with terminating a pregnancy following a prenatal diagnosis.

Who is this surgery for?

  • One or both partners are known carriers of a single-gene disorder (e.g., sickle cell anemia, thalassemia, Tay-Sachs).
  • A family history of a specific X-linked genetic disorder.
  • One partner has a chromosomal rearrangement (translocation) that can cause recurrent miscarriage or birth defects.
  • Advanced maternal age (typically over 35), which increases the risk of embryonic aneuploidy (abnormal chromosome number).
  • History of recurrent implantation failure or unexplained recurrent pregnancy loss.
  • To select an HLA-matched embryo for a sibling who requires a stem cell transplant (savior sibling).
  • Previous pregnancy or child with a chromosomal abnormality.

How to prepare

  • Comprehensive genetic counseling and risk assessment for both partners to confirm the indication for PGD.
  • Standard IVF preparation, including ovarian stimulation with fertility medications to produce multiple eggs.
  • Egg retrieval procedure under sedation.
  • Fertilization of the retrieved eggs with sperm in the lab via conventional IVF or ICSI (Intracytoplasmic Sperm Injection).
  • Embryo culture for 5-6 days until they reach the blastocyst stage.
  • Development of a specific genetic probe or test for the condition being screened, which may take several weeks.

Risks & possible complications

  • Standard risks associated with the IVF process, including ovarian hyperstimulation syndrome (OHSS) and risks from egg retrieval.
  • Potential for embryo damage during the biopsy procedure, though this risk is low in experienced labs.
  • Misdiagnosis due to technical limitations, mosaicism (where some cells in the embryo are normal and others are abnormal), or test error.
  • No normal embryos may be available for transfer, ending the cycle.
  • Ethical considerations regarding embryo selection and potential for discarding affected embryos.
  • The procedure does not guarantee a successful pregnancy or a completely healthy baby, as it screens only for the specific tested conditions.

Recovery & hospital stay

  • Physical recovery from the embryo transfer is minimal; patients can resume light activities almost immediately.
  • Patients may be prescribed progesterone supplements to support the uterine lining after the transfer.
  • A pregnancy blood test (beta-hCG) is typically scheduled 10-14 days after the embryo transfer.
  • If pregnancy is achieved, standard prenatal care is initiated, including confirmatory prenatal diagnostic testing (like CVS or amniocentesis) as recommended, as PGD is highly accurate but not 100%.
  • Emotional support is crucial, as the PGD and IVF process can be stressful; counseling may be beneficial.
  • checked Typical hospital stay: 0 days (outpatient procedure for egg retrieval and transfer)
  • checked Expected recovery time: 1-2 days (physical recovery from procedures)

Frequently Asked Questions

If you are considering preimplantation genetic diagnosis in India, these questions and answers can help you make a confident, informed decision.

Procedure cost in other countries

Here is an overview of how the estimated cost, hospital stay, and recovery time for preimplantation genetic diagnosis compare across other countries where we have data.

Country Estimated cost range Typical stay Recovery time View details
India INR 250 Thousand – 500 Thousand 0 days (outpatient procedure for egg retrieval and transfer) ~ 1-2 days (physical recovery from procedures) Know More
Turkey TRY 875 Thousand – 1.75 Million 0 days (outpatient procedure for egg retrieval and transfer) ~ 1-2 days (physical recovery from procedures) Know More
PATIENT REVIEW

Myra Sharma, a 38-year-old architect, and...

Myra Sharma, a 38-year-old architect, and her husband had endured three heartbreaking miscarriages in two years, each occurring in the first trimester. Genetic testing revealed Myra was a balanced translocation carrier, a chromosomal rearrangement that significantly increased the risk of miscarriage and genetic disorders in their children. Their fertility specialist, Dr. Kapoor, gently explained that while Myra could conceive naturally, the odds of a healthy, full-term pregnancy were very low. He recommended PGD as part of an IVF cycle to screen embryos for the specific chromosomal imbalance. The process was physically and emotionally grueling for Myra, hormone injections, egg retrieval, and the agonizing two-week wait for results. Of the eight embryos created, only two were chromosomally balanced and suitable for transfer. The first transfer was successful. Myra's pregnancy was closely monitored but progressed normally. She gave birth to a healthy baby girl. Emotionally, Myra moved from a place of profound grief and fear of never becoming a mother to cautious hope during the PGD process. After the successful birth, she felt an overwhelming sense of relief and gratitude, though she still carries a quiet empathy for the embryos that couldn't be used and the painful journey that led them here.

IVF and Reproductive Medicines for Preimplantation Genetic Diagnosis

Explore experienced ivf and reproductive medicines who regularly perform preimplantation genetic diagnosis and provide pre- and post-operative care in India.

Dr. T Geetha Anand
  • 29 Years Experience
  • IVF and Reproductive Medicine
Speaks: English, Hindi
Consult Charge ₹ 500
Available Today
December: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Salem, Salem

OPD-desk synced • Updated
Dr. Nivedita Vishwanath Adapa
  • 16 Years Experience
  • IVF and Reproductive Medicine
Speaks: English, Hindi
Consult Charge ₹ 1050
Available Today
December: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Mysore, Mysore

OPD-desk synced • Updated
Dr. Jyotsna Mirlay
  • 34 Years Experience
  • IVF and Reproductive Medicine
Speaks: English, Hindi
Consult Charge ₹ 800
Available Today
December: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Malleshwaram, Bangalore

OPD-desk synced • Updated
Dr. Nirmala Mohan
  • 26 Years Experience
  • IVF and Reproductive Medicine
Speaks: English, Hindi
Consult Charge ₹ 850
Available Today
December: 08:00 AM - 08:00 PM

MediFyr Plus Manipal Hospital Hebbal, Bangalore

OPD-desk synced • Updated
Dr. Kiran Arora
  • 25 Years Experience
  • IVF and Reproductive Medicine
Speaks: English, Hindi
Consult Charge ₹ 1500
Available Today
December: 08:00 AM - 08:00 PM

MediFyr Plus Artemis Hospital Gurgaon, Gurgaon

OPD-desk synced • Updated
Dr. Sarabpreet Singh
  • 16 Years Experience
  • IVF and Reproductive Medicine
Speaks: English, Hindi
Consult Charge ₹ 1500
Available Today
December: 08:00 AM - 08:00 PM

MediFyr Plus Artemis Hospital Gurgaon, Gurgaon

OPD-desk synced • Updated
Dr. Parul Prakash
  • 20 Years Experience
  • IVF and Reproductive Medicine
Speaks: English, Hindi
Consult Charge ₹ 1500
Available Today
December: 08:00 AM - 08:00 PM

MediFyr Plus Artemis Hospital Gurgaon, Gurgaon

OPD-desk synced • Updated