About Intracytoplasmic Morphologically Selected Sperm Injection
Key Highlights
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Uses ultra-high magnification (over 6000x) to select sperm with optimal morphology and nuclear integrity.Improves selection of sperm with minimal DNA fragmentation, potentially leading to healthier embryos.Can increase fertilization rates and embryo quality compared to standard ICSI.Particularly beneficial for cases of severe male factor infertility or previous IVF failures.May reduce the risk of miscarriage and improve pregnancy outcomes.
Who is this surgery for?
- Severe male factor infertility (e.g., very low sperm count, poor motility, or abnormal morphology).
- Previous failed fertilization attempts with conventional IVF or ICSI.
- History of poor embryo quality in prior IVF cycles.
- High levels of sperm DNA fragmentation identified through testing.
- Recurrent pregnancy loss where male factor is suspected.
- Unexplained infertility where subtle sperm abnormalities may be a factor.
How to prepare
- Comprehensive fertility evaluation of both partners, including semen analysis and hormonal assessments.
- Female partner undergoes ovarian stimulation with fertility medications to produce multiple eggs.
- Monitoring via ultrasound and blood tests to track follicular development.
- Sperm sample collection from the male partner, typically on the day of the egg retrieval.
- Pre-procedure counseling to discuss the process, expectations, and potential outcomes.
- Informed consent for the IMSI procedure as part of the IVF cycle.
Risks & possible complications
- Similar to standard IVF/ICSI risks: ovarian hyperstimulation syndrome (OHSS), multiple pregnancies, and egg retrieval complications.
- No significant added procedural risk compared to ICSI, as it is a selection enhancement.
- Potential for no normal sperm to be identified, leading to cancellation of the injection step.
- Emotional and psychological stress associated with advanced fertility treatments.
- Financial cost, as IMSI is an add-on technique with additional charges.
Recovery & hospital stay
- Immediate recovery after egg retrieval is similar to standard IVF; rest is advised for the remainder of the day.
- Mild cramping or bloating may occur and typically resolves within a few days.
- Embryo transfer is usually performed 3-5 days after fertilization, requiring a brief clinic visit.
- Post-transfer, light activity is recommended; strenuous exercise should be avoided.
- A pregnancy test is scheduled approximately 10-14 days after the embryo transfer.
- Follow-up appointments are scheduled to monitor early pregnancy if the cycle is successful.
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Typical hospital stay: 0 days (outpatient procedure)
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Expected recovery time: 1-2 days (physical recovery from retrieval), 2 weeks (to pregnancy test)
Frequently Asked Questions
If you are considering intracytoplasmic morphologically selected sperm injection in India, these questions and answers can help you make a confident, informed decision.
Top-rated hospitals in India with ivf and reproductive medicine departments and experienced surgeons are ideal for this procedure. Use MediFyr to compare facilities, reviews, and doctor profiles before you decide.
Look at the doctor’s years of experience, hospital association, patient reviews, and how often they perform intracytoplasmic morphologically selected sperm injection. MediFyr helps you compare ivf and reproductive medicines and book consultations online.
The overall cost depends on hospital category, surgeon’s experience, room type, implant or device used (if any), length of stay, tests, and post-operative care. Our team can help you get cost estimates from multiple hospitals before you decide.
Procedure cost in other countries
Here is an overview of how the estimated cost, hospital stay, and recovery time for intracytoplasmic morphologically selected sperm injection compare across other countries where we have data.
| Country | Estimated cost range | Typical stay | Recovery time | View details |
|---|---|---|---|---|
| India | INR 250 Thousand – 450 Thousand | 0 days (outpatient procedure) | ~ 1-2 days (physical recovery from retrieval), 2 weeks (to pregnancy test) | Know More |
| Turkey | TRY 875 Thousand – 1.58 Million | 0 days (outpatient procedure) | ~ 1-2 days (physical recovery from retrieval), 2 weeks (to pregnancy test) | Know More |
Ishaan Patel, a 32-year-old software engineer...
Ishaan Patel, a 32-year-old software engineer from Mumbai, had been trying to conceive with his wife for four years. Their journey began with hope but turned into a series of disappointments. Multiple standard IVF cycles had failed, with fertilization rarely occurring. Extensive testing revealed Ishaan had severe teratozoospermia, meaning over 99% of his sperm were abnormally shaped, which conventional IVF could not overcome. The embryologist, Dr. Sharma, recommended IMSI. Using high-magnification microscopy, she could visually select the most morphologically normal sperm for injection, bypassing the natural selection process that was failing. The procedure itself was a tense day of waiting while the embryology team worked. A week later, they received the call: two high-quality blastocysts had developed. One was transferred, resulting in a positive pregnancy test. Ishaan's emotional journey was marked by initial guilt and feeling 'broken,' believing he was the sole cause of their struggle. The IMSI process, by offering a tangible, scientific solution to his specific problem, alleviated that burden. The successful outcome transformed his guilt into profound relief and a fierce protectiveness for the pregnancy, finally allowing him to feel like an active participant in creating their family.
IVF and Reproductive Medicines for Intracytoplasmic Morphologically Selected Sperm Injection
Explore experienced ivf and reproductive medicines who regularly perform intracytoplasmic morphologically selected sperm injection and provide pre- and post-operative care in India.
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