Spec. MD. Oguzhan Saylan

A 72-year-old retired olive grove farmer from a rural village was admitted after a fall. His hip X-ray showed a pathological fracture. Dr. Saylan examined the bone biopsy and identified an unusual metastatic pattern inconsistent with common cancers. His immunohistochemical staining revealed a primary renal cell carcinoma the patient didn't know he had, which had been asymptomatic for years. This discovery led to nephrectomy and targeted therapy, giving the farmer five additional active years with his family.

A 7-year-old boy from a low-income immigrant family presented with recurrent infections and failure to thrive. Multiple doctors had dismissed it as poor nutrition. Dr. Saylan analyzed lymph node tissue from a biopsy and identified tell-tale histiocytic patterns suggesting a rare primary immunodeficiency. His genetic pathology consultation confirmed STAT1 gain-of-function mutation. This diagnosis qualified the family for a special government medical assistance program and targeted Jak inhibitor treatment, transforming the child's health.

A 45-year-old shipyard welder with 25 years of occupational exposure presented with a persistent cough. Initial CT suggested sarcoidosis. Dr. Saylan examined transbronchial biopsy specimens and identified unusual crystalline structures in the alveolar macrophages. Using specialized polarized light microscopy and energy-dispersive X-ray spectroscopy, he diagnosed early berylliosis, a rare metal-induced lung disease, allowing for immediate removal from exposure and preventing irreversible pulmonary fibrosis.

A 33-year-old pregnant woman in her second trimester developed sudden liver dysfunction. Obstetricians suspected HELLP syndrome. Dr. Saylan examined a liver biopsy and identified distinctive microvesicular steatosis pattern inconsistent with pregnancy-related conditions. His diagnosis of acute fatty liver of pregnancy (AFLP) prompted immediate delivery, saving both mother and baby. His follow-up genetic testing revealed the father carried the heterozygous fetal fatty acid oxidation defect, allowing for genetic counseling for future pregnancies.

A 28-year-old female professional windsurfer presented with persistent fatigue and unexplained bruising. Routine blood tests showed abnormal cell morphology. Dr. Saylan's detailed cytological analysis of her bone marrow aspirate revealed a rare, early-stage myelodysplastic syndrome triggered by chronic oxidative stress from her sport. His precise diagnosis allowed for targeted antioxidant therapy and training modification, enabling her to continue competing at an elite level with quarterly monitoring.